The killing of Macduff's entire household, his wife, children, servants is a turning point in the play for Macbeth. He is deranged with paranoia, using murder to protect his power, striking out at innocent women and children. He is anticipating an assault from Macduff, and intends to kill him and anyone else at his home in order to prevent any challenge from him.
The murder of Macduff's family begins the descent into total madness for both Macbeth and Lady Macbeth. She, in particular, cannot see the justification for the murders, and becomes emotionally isolated from her husband.
Macbeth, is tortured by fear and uncertainty and becomes obsessed with keeping his power and authority as king.
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