Macbeth experiences a crisis of conscience once he kills Duncan, which results in a sense of overwhelming guilt. He is tormented from the very first moment that he is crowned.
Macbeth does not enjoy his time as king. His mental stability begins to deteriorate when he is celebrating his ascension to the throne. At this celebratory dinner, he is confronted by the ghost of Banquo, his latest victim. From that time on, he experiences extreme paranoia, believing that everyone is out to get him. He has no peace, he can't sleep, he can't eat, and he loses his loving relationship with Lady Macbeth, as he isolates himself emotionally, drawn into a private hell dominated by fear of losing his crown.
His conflict is so extreme, he is at war both internally and externally, literally with the forces of nature which have been distured by Macbeth's act of regicide, killing a rightful and just king.
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