In "Hamlet", what does Hamlet mean when he is contemplating Yorick's skull and says the following? "Now get you to my lady's chamber, and tell her,...

He is referring to women AND death, and how the two mixing is not a very amusing scenario.  As Hamlet is contemplating Yorick's skull, he is amazed that this man, who was "a fellow of infinite jest, of most excellent fancy", who played with Hamlet, who kissed Hamlet, is reduced to this grinning skull.  He later awes that even Alexander the great and Caesar were reduced to dust, just like Yorick.  Hamlet is slightly disgusted at the rotted skull, and at the stench of the grave. So, when he states the above quote, he is referring to women, who spend so much time "painting" their faces with make-up "an inch thick", because in the end, they will end up just like Yorick, a rotting and smelly skull.  He tells Yorick to "make her laugh at that", at the awful reality of death.  Not a very funny proposition, indeed.